S-Nitrosoglutathione Acts as a Small Molecule Modulator of Human Fibrin Clot Architecture
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S-Nitrosoglutathione Acts as a Small Molecule Modulator of Human Fibrin Clot Architecture
BACKGROUND Altered fibrin clot architecture is increasingly associated with cardiovascular diseases; yet, little is known about how fibrin networks are affected by small molecules that alter fibrinogen structure. Based on previous evidence that S-nitrosoglutathione (GSNO) alters fibrinogen secondary structure and fibrin polymerization kinetics, we hypothesized that GSNO would alter fibrin micro...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0043660